You can't miss this huge building across the street from Macy's and the Empire State Building. Every store in the world is in here as well as restaurants and galleries. The neon makes this place much more like an american mall than the classier South Street Seaport area or Trump Towers. Although not particularly unique to New York, it is still a shopper's paradise.
6th Ave and 33rd Street, (212) 465-0500